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Tegobuvir (GS-9190) potency against HCV chimeric replicons derived from consensus NS5B sequences from genotypes 2b, 3a, 4a, 5a, and 6a

✍ Scribed by Kelly A. Wong; Simin Xu; Ross Martin; Michael D. Miller; Hongmei Mo

Book ID
113948452
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
237 KB
Volume
429
Category
Article
ISSN
0042-6822

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The Schiff base ligand {3-hydroxyl-5-(hydroxymethyl)-2-methylpyridine-4-yl-methylene}benzohydrazide hydrochloride monohydrated {(hhmmbH)ClÁH 2 O} (1) was prepared by reaction of pyridoxine hydrochloride with benzoic acid hydrazide. The reaction of 1 with [VO(acac) 2 ] and triethylamine yields the ne