Growing up on the streets: why B-cell de
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Sarah E Townsend; Bennett C Weintraub; Christopher C Goodnow
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Article
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1999
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Elsevier Science
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English
β 280 KB
hy do B cells Γgrow up on the streetsΓ? Much of T-cell development occurs in the thymus, geographically sequestered from the sites of active immune responses. This cloistered environment ensures that many self-reactive T cells are eliminated before joining the mature T-cell repertoire. B cells also