Activation of MMP-2 by human GCT23 giant
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Anna Teti; Antonietta R. Farina; Ida Villanova; Antonella Tiberio; Antonella Tac
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Article
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1998
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John Wiley and Sons
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French
⚖ 293 KB
We show that osteopontin (OPN), bone sialoprotein (BSP) and GRGDSP peptides, in solution, induce activation of metalloproteinase-2 (MMP-2) secreted by human GCT23 giant cell tumour cells. Activation of MMP-2 is RGD sequence dependent, possibly involves anti-alphaVbeta3 integrins, is preceded by a ch