Technical note: Activation of the plasma coagulation system induced by some biomaterials
✍ Scribed by Cenni, E. ;Ciapetti, G. ;Cervellati, M. ;Cavedagna, D. ;Falsone, G. ;Gamberini, S. ;Pizzoferrato, A.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 393 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
The ability of some biomaterials to activate plasma coagulation system was examined in vitro. After contact of plateletrich plasma with biomaterials, some markers of the thrombin formation process, i.e., fragment 1 + 2 and fibrinopeptide A, and some inhibitors of the blood coagulation mechanism were tested. Fragment 1 + 2 and fibrinopeptide A were found to be increased by all of the materials, though to a different extent. In particular, fragment 1 + 2 and fibrinopeptide A were significantly increased upon contact with polybutylene terephthalate and with collagen coated poly-ethylene terephthalate, respectively. Also, antithrombin I11 was shown to decrease following exposure to biomaterials, but statistical significance was found only for polyethylene terephthalate and polyvinylacetate. As a result of this wide range of variability in the parameters, it is advisable to explore the plasma coagulation system with a multiparametric approach in which thrombin formation and coagulation inhibitors are thoroughly investigated.