Technetium—aspirin molecule complexes

✍ Scribed by Anwar S. El-Shahawy; R. M. Mahfouz; Aref A. M. Aly; Maher El-Zohry

• Publisher: Wiley (John Wiley & Sons)
• Year: 2007
• Tongue: English
• Weight: 344 KB
• Volume: 56
• Category: Article
• ISSN: 0268-2575
• DOI: 10.1002/jctb.280560302

✦ Synopsis

Technetium-aspirin and technetium-aspirin-like molecule complexes were prepared. The structure of N-acetylanthranilic acid (NAA) has been decided through CNDO calculations. The ionization potential and electron affinity of the NAA molecule as well as the charge densities were calculated. Comparative studies of the electronic absorption spectra of acetylthiosalicylic acid (ATS) and aspirin (Asp) reveal the structure resemblance in which the acetyl carbonyl group is perpendicular to the plane of the corresponding organic acid. The studies of the electronic absorption spectra of NAA and anthranilic acid reveal the planarity of the NAA molecule. The electronic absorption spectra of Tc(VkAsp and Tc(V)-ATS complexes have two characteristic absorption bands at 450 and 600 nm, but the Tc(V)-NAA spectrum has one characteristic band at 450 nm. As a comparative study, Mo-ATS complex was prepared and its electronic absorption spectrum is comparable with the Tc-ATS complex spectrum.