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The development of novel radiotracers is often impaired by the time required to determine the uptake and ultimate fate of agents at a cellular level. At present, determining cellular uptake and distribution often involves substituting the radioactive entity with a fluorescent prosthetic group, which
In rapidly growing tumors such as glioma, the nucleoside analogue 5-lodo-2-deoxyuridine is used as efficient diagnostic agent and provides a means to determine the proliferative activity of the tumor. On the other hand, (radiolabeled) 5-ethyl-uridine analogues (targeting the viral thymidine kinase 1
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