✦ LIBER ✦
Technetium mixed-ligand complexes containing bidentate phosphines and monodentate thiol ligands. Preparation, in vitro data and detection of a certain heart affinity
✍ Scribed by Ulrich Abram; Gudrun Kampf; Sonja Abram; Rudolf Münze
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 572 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
✦ Synopsis
TcO, is reduced by a mixture of phosphine and thiol ligands to yield cationic complexes in which both ligands are coordinated. Polar and lipophilic properties of the products can easily be controlled by variation of either of the ligands. The yields are always high. Potential heart affinity of the compounds was screened by means of the isolated perfused rat heart. Some of the complexes show significant heart uptake and good retention in the myocardial tissue.