Technetium-99m labelling of bis-oxime ligands

✍ Scribed by Graham E. Jackson; Michael J. Byrne; Hashiem Fakier; Roger Hunter; Marianne Woudenberg

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 588 KB
• Volume: 45
• Category: Article
• ISSN: 0969-8043
• DOI: 10.1016/0969-8043(94)90201-1

✦ Synopsis

The synthesis and labelling of a new bis-amide-oxime ligand E,E-2,9-bis(hydroxyimino)-4,7-diaza 5,6-dioxodecane (AdO) with 99mTc has been achieved. Protein binding, partition coefficient and tissue distribution of this complex and two related bis-amine-oxime ligands is reported. The biodistribution of the complexes are disappointing with only limited brain and myocardial uptake. Structures for the complex are postulated.