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TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK

✍ Scribed by Alamdar Hussain; Liang Yu; Rani Faryal; Dara K. Mohammad; Abdalla J. Mohamed; C. I. Edvard Smith

Book ID
111313935
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
214 KB
Volume
278
Category
Article
ISSN
1432-1327

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The Tec family of cytoplasmic tyrosine k
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✍ C.I. Edvard Smith; Tahmina C. Islam; Pekka T. Mattsson; Abdalla J. Mohamed; Best 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 549 KB

## Abstract Cytoplasmic protein‐tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans. The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cau