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TDP-43 in differential diagnosis of motor neuron disorders

✍ Scribed by Dennis W. Dickson; Keith A. Josephs; Catalina Amador-Ortiz


Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
383 KB
Volume
114
Category
Article
ISSN
0001-6322

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TDP-43 A315T mutation in familial motor
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## Abstract To identify novel causes of familial neurodegenerative diseases, we extended our previous studies of TAR DNA‐binding protein 43 (TDP‐43) proteinopathies to investigate __TDP‐43__ as a candidate gene in familial cases of motor neuron disease. Sequencing of the __TDP‐43__ gene led to the