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TCF Transcription Factors, Mediators of Wnt-Signaling in Development and Cancer

✍ Scribed by Mascha van Noort; Hans Clevers

Book ID
115598931
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
149 KB
Volume
244
Category
Article
ISSN
0012-1606

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T cell factor/lymphocyte enhancer factor (Tcf/Lef) transcription factors complex with the transcriptional co-activator g -catenin to transduce Wnt signals in a variety of developmental systems. The prototypic family member Tcf-1 is highly expressed in T lineage cells. Tcf1 -/- mice are defective in