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TCDD and PAH-induced CYP1A/B gene expression in H4IIE rat hepatoma cells

โœ Scribed by Sonja Kaisarevic; Vanja Dakic; Jelena Hrubik; Zorana Vujin; Kristina Pogrmic-Majkic; Svetlana Fa; Branka Glisic; Radmila Kovacevic

Book ID
116925264
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
85 KB
Volume
211
Category
Article
ISSN
0378-4274

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## Abstract In the rat, expression of the __CYP1A1__ gene is closely associated with arylhydrocarbon hydroxylase (AHH) enzyme activity. AHH is an inducible enzyme activity known to play an important role in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic and carcinogenic m