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Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

✍ Scribed by Durmus Burgucu, Kenan Guney, Duygu Sahinturk, Irem Hicran Ozbudak, Deniz Ozel, Gulay Ozbilim, Ugur Yavuzer


Book ID
119897518
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
456 KB
Volume
12
Category
Article
ISSN
1471-2407

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## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci