## Abstract Gap junctional intercellular communication (GJIC) permits coordinated cellular activities during developmental and differentiation processes. In bone, the involvement of the gap junctional protein, connexin‐43 (Cx43), and of GJIC in osteoblastic differentiation and mineralization of the
Tbx2Represses Expression of Connexin43 in Osteoblastic-like Cells
✍ Scribed by J.-R. Chen; B. Chatterjee; R. Meyer; J.C. Yu; J.L. Borke; C.M. Isales; M.L. Kirby; C.W. Lo; R.J. Bollag
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 483 KB
- Volume
- 74
- Category
- Article
- ISSN
- 1432-0827
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Extensive cell‐cell‐coupling via gap junctions has been suspected to play an essential role for osteoblast development. Here, osteoblast‐like cells (OBL) from connexin(Cx)43 knock out mice were used to explore the role of Cx43 for osteoblast differentiation. Primary cultures of OBL were
## Abstract We used both pharmacological and gene knockout approaches to elucidate the specific roles played by the Jun‐N‐terminal kinase (JNK) and NFκB pathways downstream of TNF‐α in the context of connexin43 (__Cx43__) gene expression. We demonstrate that TNF‐α reduces the expression of __Cx43__
Connexin43 (Cx43) forms gap junctions that mediate intercellular communication between osteoblasts. We have examined the effects of prostaglandin E 2 (PGE 2 ) and parathyroid hormone (PTH) on gap junctional communication in the rat osteogenic sarcoma cells UMR 106-01. Incubation with either PGE 2 o
## Abstract Gap junctions are cellular structures which permit direct exchanges of small molecules from cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has been observed that the inhibition of this type of intercellular communication is often associated with