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Taxol inhibits osteoclastic bone resorption in vitro

✍ Scribed by Hall, T.J.; Jeker, H.; Schaueblin, M.

Book ID
121915999
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
237 KB
Volume
16
Category
Article
ISSN
8756-3282

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Taxol inhibits osteoclastic bone resorpt
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✍ T. J. Hall; H. Jeker; M. Schaueblin πŸ“‚ Article πŸ“… 1995 πŸ› Springer 🌐 English βš– 251 KB

We have examined the effect of the anti-tumor compound taxol, on osteoclastic bone resorption. In the bone slice assay, taxol (0.1-0.001 microM) dose-dependently inhibited bone resorption with an IC50 of 0.08 microM. Osteoclast survival on bone slices was unaffected by 0.01-1 microM taxol, but 10 mi

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The effects of Zeolite A on bone resorbing activity of highly purified avian osteoclasts were analyzed. The present study demonstrates that when 100 pg/ml of acid-treated Zeolite A is added to the media the number of pits per osteoclast is reduced 3-fold at 24 h after treatment. Secreted cathepsin B