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Taxane-monoclonal antibody covalent conjugates for targeted chemotherapy of cancer

Book ID
117659766
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
346 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract Two kinds of immunoconjugate (T‐3M and T‐11M) of murine monoclonal antibody with mitomycin C (MMC) were developed using spacers containing a disulfide (T‐3M) or thiocarbamate (T‐11M) bond. A murine monoclonal antibody (NCC‐LU‐243) raised against a human small cell lung carcinoma cell li