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Tautomeric and Microscopic Protonation Equilibria of Anthranilic Acid and Its Derivatives

✍ Scribed by Zapała, Lidia; Woźnicka, Elżbieta; Kalembkiewicz, Jan

Book ID
125364428
Publisher
Springer US
Year
2014
Tongue
English
Weight
385 KB
Volume
43
Category
Article
ISSN
0095-9782

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Microscopic Protonation/Deprotonation Eq
Microscopic Protonation/Deprotonation Equilibria of the Anti-Inflammatory Agent Piroxicam
✍ Krisztina Takács-Novák; József Kökösi; Benjámin Podányi; Béla Noszál; Ruey-Shiua 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 German ⚖ 586 KB

The microscopic ionization behavior of piroxicam was investigated using two different approaches, ie., direct UV spectroscopy and an indirect analogue approach (deductive method). The best microscopic pK, values (pK,,, = 4.60, pK,,, = 5.40, pKa2, = 2.72, and pK,,, = 1.92) were obtained by the deduct