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Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1

✍ Scribed by Thomas Pusl; Timo Vennegeerts; Ralf Wimmer; Gerald U. Denk; Ulrich Beuers; Christian Rust

Book ID: 116296192
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 138 KB
Volume: 367
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.12.122

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Tauroursodeoxycholic acid (TUDCA) is a cytoprotective bile acid frequently prescribed to patients with cholestatic diseases. Several mechanisms of action have been investigated, but the possibility that cyclic adenosine monophosphate responsive element binding protein (CREB), a transcription factor