Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes
β Scribed by U Beuers; DC Throckmorton; MS Anderson; CM Isales; W Thasler; GA Kullak-Ublick; G Sauter; HG Koebe; G Paumgartner; JL Boyer
- Book ID
- 119755386
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 241 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0016-5085
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π SIMILAR VOLUMES
The protein kinase C (PKC) family of isoenzymes plays a key role in the regulation of hepatocellular secretion. The hydrophobic and cholestatic bile acid, taurolithocholic acid (TLCA), acts as a potent Ca++ agonist in isolated hepatocytes. However, its effect on PKC isoforms has not been elucidated.
nases. These results suggest that PTK, Ras, and PKC Hepatocyte growth factor (HGF) stimulated mitogenplay roles in MAP kinase activation induced by HGF and activated protein (MAP) kinases and MAP kinase kinase that MAP kinase activation resulting in AA release is in primary cultured rat hepatocytes.