A protective effect of taurine on morphological alterations induced in isolated ROS by remotion of divalent cations is described. ROS damage is not observed when sodium or chloride is replaced by impermeant ions or in the presence of nifedipine (10 microM). An increased accumulation of 22Na but not
β¦ LIBER β¦
Taurine and hypotaurine inhibit light-induced lipid peroxidation and protect rod outer segment structure
β Scribed by H. Pasantes-Morales; C. Cruz
- Book ID
- 118870067
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 267 KB
- Volume
- 330
- Category
- Article
- ISSN
- 0006-8993
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Exposure of isolated frog rod outer segments (ROS) to ferrous sulfate in a Krebsbicarbonate medium causes a time-dependent disruption of the membrane organization of the discs. Ferrous sulfate also causes ROS swelling and aggregation. Addition of taurine (5-20 mM) and zinc sulfate (250 pM) to the in