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Tau Polymerization: Role of the Amino Terminus †

✍ Scribed by Gamblin, T. Chris; Berry, Robert W.; Binder, Lester I.

Book ID
126886480
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
149 KB
Volume
42
Category
Article
ISSN
0006-2960

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## Abstract The neuropathology of Alzheimer's disease (AD) and other tauopathies is characterized by filamentous deposits of the microtubule‐associated protein tau, but the relationship between tau polymerization and neurotoxicity is unknown. Here, we examined effects of filamentous tau on fast axo