Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

Dystrophic (senescent) rather than activ

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

✍ Wolfgang J. Streit; Heiko Braak; Qing-Shan Xue; Ingo Bechmann 📂 Article 📅 2009 🏛 Springer-Verlag 🌐 English ⚖ 598 KB

Decreased levels of PSD95 and two associ

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

✍ Rukhsana Sultana; William A. Banks; D. Allan Butterfield 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

## Abstract Alzheimer's disease (AD) is the most common form of dementia and is pathologically characterized by senile plaques, neurofibrillary tangles, synaptic disruption and loss, and progressive neuronal deficits. The exact mechanism(s) of AD pathogenesis largely remain unknown. With advances i