Task Specific Onium Salt as Soluble Support in Multicomponent Synthesis of 4-Aryl-2-amino-3-ethoxycarbonyl-naphthopyrans

✍ Scribed by Cuifen Lu; Li Zhang; Guichun Yang; Zuxing Chen

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 77 KB
• Volume: 28
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.201190023

✦ Synopsis

Abstract

In this paper was presented an application of task specific onium salt as soluble support in multicomponent synthesis of 2‐amino‐3‐ethoxycarbonyl‐naphthopyrans. The starting task‐specific onium salt was functionalized in good yield with chloroethyl alcohol, followed by three steps containing esterification, three components reaction and cleavage from onium salt to afford naphthopyrans in 60% –88% overall yields. All of the products were characterized by IR, ^1^H NMR, ^13^C NMR and MS techniques.