Targetry and radiochemical methods for the simultaneous cyclotron production of no-carrier-added radiopharmaceutical-quality 100Pd, 97Ru and 101mRh
✍ Scribed by Manuel C. Lagunas-Solar; Mario J. Avila; Paul C. Johnson
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 811 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
Target-dissolution and radiochemical methods were investigated to optimize the simultaneous production of radiopharmaceutical-quality, no-carrier-added (NCA) 3.63-d 100Pd, 2.88-d 97Ru and 4.26-d 101mRh. These radionuclides have potential as radiotracer labels and/or as short-range dose emitters for use with specific-function radiopharmaceuticals being investigated for radioimmunotherapy applications. Metallic Rh (100% 103Rh) and RhCl3 X 3H2O were used as target materials. After bombardment with high energy protons these targets were subjected to a combination of procedures (i.e. electrolytic dissolution, ion-exchange, and solvent extraction) in order to separate the desired radionuclides. The use of a single cyclotron target in combination with several radiochemical processes were investigated to simultaneously produce these radionuclides in high-specific activities and radiochemical forms suitable for radiopharmaceutical syntheses.