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Targeting β2-Microglobulin Mediated Signaling as a Novel Therapeutic Approach for Human Renal Cell Carcinoma

✍ Scribed by Nomura, Takeo; Huang, Wen-Chin; Seo, Seongil; Zhau, Haiyen E.; Mimata, Hiromitsu; Chung, Leland W.K.

Book ID: 121682823
Publisher: Lippincott Williams and Wilkins
Year: 2007
Tongue: English
Weight: 801 KB
Volume: 178
Category: Article
ISSN: 0022-5347
DOI: 10.1016/j.juro.2007.03.007

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## Abstract ## Background Advanced renal cell carcinoma (RCC) frequently develops skeletal metastasis and is highly resistant to conventional therapies. We hypothesized that the osteocalcin (OC) promoter may be a promising gene delivery system for RCC targeted gene therapy because osteotropic tumo