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Targeting αV-integrins decreased metastasis and increased survival in a nude rat breast cancer brain metastasis model

✍ Scribed by Y. Jeffrey Wu, Leslie L. Muldoon, Seymur Gahramanov, Dale F. Kraemer, Deborah J. Marshall, Edward A. Neuwelt


Book ID
118807094
Publisher
Springer US
Year
2012
Tongue
English
Weight
652 KB
Volume
110
Category
Article
ISSN
0167-594X

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The MA1 I human breast-cancer cell line was established with cells isolated from a bone-marrow sam le using immunomagnetic beads conjugated to the anti-MUt!I antibody BM-2. The cell line showed a selective preference for metastasising to the brain in athymic nude mice. Following injection of MA1 I c