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Targeting tumor angiogenic vasculature using polymer–RGD conjugates

✍ Scribed by Amitava Mitra; Justin Mulholland; Anjan Nan; Edwina McNeill; Hamidreza Ghandehari; Bruce R. Line

Book ID
113690739
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
351 KB
Volume
102
Category
Article
ISSN
0168-3659

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## Abstract ## Background Targeting to integrin receptor α~ν~β~3~ by RGD peptides seems to be a promising approach for gene delivery to proliferating endothelial cells of tumor metastases. PEGylation of cationic polymers offers a reduction of non‐specific binding to cell surfaces. However, little