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TARGETING THE RNA-BINDING PROTEIN HuR HAS POTENT ANTI-TUMOR EFFECTS IN HUMAN RENAL CELL CARCINOMA

โœ Scribed by Danilin, Sabrina; Thomas, Lionel; Sourbier, Carole; Rothhut, Sylvie; Lindner, Veronique; Helwig, Jean-Jacques; Jacqmin, Didier; Lang, Herve; Massfelder, Thierry


Book ID
122980943
Publisher
Lippincott Williams and Wilkins
Year
2008
Tongue
English
Weight
123 KB
Volume
179
Category
Article
ISSN
0022-5347

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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R