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Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

✍ Scribed by Chang, Katherine; Svabek, Catherine; Vazquez-Guillamet, Cristina; Sato, Bryan; Rasche, David; Wilson, Strother; Robbins, Paul; Ulbrandt, Nancy; Suzich, JoAnn; Green, Jonathan; Patera, Andriani C; Blair, Wade; Krishnan, Subramaniam; Hotchkiss, Richard

Book ID
121563865
Publisher
Springer (Biomed Central Ltd.)
Year
2014
Tongue
English
Weight
929 KB
Volume
18
Category
Article
ISSN
1466-609X

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The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis
✍ Amalia P. Raptopoulou; George Bertsias; Dimitrios Makrygiannakis; Panagiotis Ver πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 607 KB

## Abstract ## Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in peripheral tolerance through inhibition of T cells at the level of synovial tissue. The aim of this study was