Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
โ Scribed by Suzanne L Topalian; Charles G Drake; Drew M Pardoll
- Book ID
- 116373485
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 383 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
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## Abstract Expression by DCs of coโinhibitory molecules such as programmed death ligandโ1 (PDโL1/B7โH1/CD274), a member of the B7 superfamily, is crucial for the downregulation of Tโcell responses and the maintenance of immune homeostasis. Exposure of immature DCs to dangerโassociated molecular pa
## Abstract Human tumors frequently escape immune destruction, despite the presence of cyototoxic T cells (CTL) recognizing tumorโassociated antigens (TAA). We have previously shown that programmed death ligandโ1 (PDโL1), a recently identified ligand of the B7 superfamily, is expressed on murine tu