Targeting the interleukin-6 receptor: A new treatment for systemic juvenile idiopathic arthritis?
✍ Scribed by Fabrizio de Benedetti; Alberto Martini
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 79 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0004-3591
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## Abstract We report an excellent clinical response to treatment with a humanized anti–interleukin‐6 receptor antibody, tocilizumab, in a patient with progressive amyloid A (AA) amyloidosis complicating very active juvenile idiopathic arthritis. Treatment with tocilizumab immediately normalized th
## Abstract ## Objective Macrophage activation syndrome is characterized by an overwhelming inflammatory reaction driven by excessive expansion of T cells and hemophagocytic macrophages. Levels of soluble interleukin‐2 receptor α (sIL‐2Rα) and soluble CD163 (sCD163) may reflect the degree of activ