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Targeting the insulin-like growth factor axis in the therapy of colorectal carcinoma liver metastasis

✍ Scribed by Charles A. Portera Jr; Hisashi Shinohara; Taka Mima; Alex Miller; Rachel Tsan; Desmond Mascarenhas; Robert Radinsky

Book ID
117734186
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
162 KB
Volume
10
Category
Article
ISSN
1096-6374

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## Abstract Apart from hepatic stellate cells (HSC), liver myofibroblasts (MF) represent a second mesenchymal cell population involved in hepatic fibrogenesis. The IGF system including the insulin‐like growth factors I and II (IGF‐I, ‐II), their receptors (IGF‐I receptor, IGF‐IR; IGF‐II/mannose 6‐p