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Targeting the Dimerization Interface of HIV-1 Protease: Inhibition with Cross-Linked Interfacial Peptides

✍ Scribed by Zutshi, Reena; Franciskovich, Jeff; Shultz, Michael; Schweitzer, Barbara; Bishop, Patricia; Wilson, Matt; Chmielewski, Jean

Book ID
127120967
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
277 KB
Volume
119
Category
Article
ISSN
0002-7863

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HIV-1 protease (HIV-1 PR), which is encoded by retroviruses, is required for the processing of gag and pol polyprotein precursors, hence it is essential for the production of infectious viral particles. In vitro inhibition of the enzyme results in the production of progeny virions that are immature