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Targeting Smads to Restore Transforming Growth Factor-β Signaling and Regulatory T-Cell Function in Inflammatory Bowel Disease

✍ Scribed by Deanna D. Nguyen; Scott B. Snapper

Book ID
119760864
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
492 KB
Volume
136
Category
Article
ISSN
0016-5085

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Background: CD4 þ Foxp3 þ regulatory T cells (Treg) inhibit Tcell proliferation in vitro and are effective in suppressing colitis in mouse models. Tumor necrosis factor (TNF)-a, which is centrally involved in Crohn's disease (CD) pathogenesis, also impairs Treg function. Here we investigated the inf