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Targeting primary human leukaemia cells with RNA interference: Bcr-Abl targeting inhibits myeloid progenitor self-renewal in chronic myeloid leukaemia cells

✍ Scribed by Jane ME Withey; Stephen B Marley; Jaspal Kaeda; Amanda J Harvey; Mark R Crompton; Myrtle Y Gordon

Book ID: 108673156
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 102 KB
Volume: 129
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2005.05468.x

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## Abstract Chronic myeloid leukemia (CML) arises as a consequence of the expression of a chimeric fusion protein, p210BCR‐ABL1, which is localized to the cytoplasm and has constitutive protein tyrosine kinase activity. Extensive publications report that p210BCR‐ABL1 complexed with multiple cytopla