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Targeting p27Kip1 protein: its relevance in the therapy of human cancer

โœ Scribed by Borriello, Adriana; Bencivenga, Debora; Criscuolo, Maria; Caldarelli, Ilaria; Cucciolla, Valeria; Tramontano, Annunziata; Borgia, Alessia; Spina, Annamaria; Oliva, Adriana; Naviglio, Silvio

Book ID
115454516
Publisher
Informa plc
Year
2011
Tongue
English
Weight
537 KB
Volume
15
Category
Article
ISSN
1472-8222

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Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways th