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Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions

✍ Scribed by Dagmar Hartung; Michael Schäfers; Shinichiro Fujimoto; Bodo Levkau; Navneet Narula; Klaus Kopka; Renu Virmani; Chris Reutelingsperger; Leo Hofstra; Frank D. Kolodgie; Artiom Petrov; Jagat Narula

Book ID
105963095
Publisher
Springer
Year
2007
Tongue
English
Weight
388 KB
Volume
34
Category
Article
ISSN
0340-6997

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Novel solubility-switchable MRI agent al
Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model
✍ Réjean Lebel; Beata Jastrzębska; Hélène Therriault; Marie-Michèle Cournoyer; J. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 918 KB

## Abstract A novel MRI proteinase‐modulated contrast agent (PCA) was developed to detect the activity of the proinvasive enzyme matrix metalloproteinase‐2 (MMP‐2) in vivo. The PCA2‐switch agent incorporates a solubility switch, where cleavage of a peptide substrate by MMP‐2 decreases the water sol