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Targeting NF-κB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth

✍ Scribed by Michel Jourdan; Jérôme Moreaux; John De Vos; Dirk Hose; Karène Mahtouk; Matthieu Abouladze; Nicolas Robert; Marion Baudard; Thierry Rème; Angela Romanelli; Hartmut Goldschmidt; Jean-François Rossi; Michel Dreano; Bernard Klein


Book ID
108675259
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
673 KB
Volume
138
Category
Article
ISSN
0007-1048

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Multiple myeloma (MM) is a fatal lymphoid malignancy that is incurable with conventional modalities of chemotherapy. Strong and constitutive activation of nuclear factor kappa B (NF-kappaB) is a common characteristic of MM cells. In our study we successfully target NF-kappaB with a novel NF-kappaB i