Targeting miR-506 in primary biliary cirrhosis to support the HCO3− umbrella
✍ Scribed by Rui E. Castro; Cecília M.P. Rodrigues
- Book ID
- 119218587
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- French
- Weight
- 224 KB
- Volume
- 36
- Category
- Article
- ISSN
- 2210-7401
No coin nor oath required. For personal study only.
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Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the serum of more than 95% of patients with primary biliary cirrhosis (PBC), the major epitope being the inner lipoyl domain of the E2 component. Immunoblotting suggests a similar prevalence of antibodies to a tightly associat
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of antimitochondrial antibodies (AMA) directed primarily against the E2 subunits of the pyruvate dehydrogenase complex, the branched chain 2-oxo-acid dehydrogenase complex, the 2-oxoglutarate dehydrogenase c