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Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis

โœ Scribed by Chatterjee, A; Chang, X; Nagpal, J K; Chang, S; Upadhyay, S; Califano, J; Trink, B; Sidransky, D

Book ID
109970623
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
440 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract Within the central nervous system (CNS), there is a differential susceptibility among cell types to certain pathological conditions believed to involve oxidative stress. Oligodendrocytes are extremely sensitive to oxidative stress, which correlates with a decreased ability to repair dam