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Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma

✍ Scribed by Xie, X; Piao, L; Bullock, B N; Smith, A; Su, T; Zhang, M; Teknos, T N; Arora, P S; Pan, Q


Book ID
120308847
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
856 KB
Volume
33
Category
Article
ISSN
0950-9232

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## Abstract Besides well‐known risk factors such as tobacco use and alcohol consumption, oncogenic human papillomavirus (HPV) infection also has recently been suggested to promote head and neck tumorigenesis. HPV is known to cause cancer by inactivation of cell cycle regulators p53 and pRb via expr