Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors

✍ Scribed by Brian Lohse; Anders L. Nielsen; Jan B. L. Kristensen; Charlotte Helgstrand; Paul A. C. Cloos; Lars Olsen; Michael Gajhede; Rasmus P. Clausen; Jesper L. Kristensen

• Book ID: 101547524
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 342 KB
• Volume: 123
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.201101849

✦ Synopsis

Scheme 1. Proposed mechanism of JmjC catalysis. [8] HDM = histone demethylase.