✦ LIBER ✦

Targeting growth factor and cytokine receptors with recombinant peptide libraries

✍ Scribed by William J Dower

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 639 KB
Volume: 2
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(98)80005-7

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✦ Synopsis

The single-transmembrane-spanning receptors of cytokines and growth factors have historically proven resistant to the small-molecule screening efforts of the pharmaceutical industry. Advances in combinatorial library approaches to ligand discovery have begun to show success with these targets. There are several recent reports of peptides, derived from randomly assembled collections of L-peptides expressed in recombinant display vectors, that are high-affinity antagonists and even agonists of these receptors. These results indicate that molecules much smaller than the natural protein factors can interact effectively with these receptors, and this may lead the way to the discovery of even smaller nonpeptidic agents.

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