Targeting endothelium for gene therapy via receptors up-regulated during angiogenesis and inflammation

Liver receptor homolog-1 is critical for

Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration

✍ Carolien Out; Jurre Hageman; Vincent W. Bloks; Han Gerrits; Maarten D. Sollewijn 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

Liver receptor homolog-1 (LRH-1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH-1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis. However, hepatic Cyp7a1 mRNA levels were not reduced upon hepatocyte-specific Lrh-1 deletion