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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma

✍ Scribed by Mohand-Akli Boukhiar,Claudine Roger,Julie Tran…


Book ID
126381486
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
761 KB
Volume
2
Category
Article
ISSN
2162-3619

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Cross-linking of the B cell antigen receptor (BCR) with an anti-IgM antibody has been shown to induce dramatic apoptosis in type I Burkitt's lymphoma (BL) cells. However, the apoptotic mechanism triggered via BCR remains unknown. Here we reports a mechanism of BCR ligation-induced apoptosis involvin