Targeting DNA methyltransferase in cancer
β Scribed by Moshe Szyf
- Book ID
- 110231377
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 896 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0167-7659
No coin nor oath required. For personal study only.
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DNA methylation is an essential epigenetic modification. In bacteria, it is involved in gene regulation, DNA repair, and control of cell cycle. In eukaryotes, it acts in concert with other epigenetic modifications to regulate gene expression and chromatin structure. In addition to these biological r
## Abstract Recent studies have shown that cytosineβ5 methylation at CpG islands in the regulatory sequence of a gene is one of the key mechanisms of inactivation. The enzymes responsible for CpG methylation are DNA methyltransferase (DNMT) 1, DNMT3a, and DNMT3b, and the enzyme responsible for deme