Successful gene therapy depends on the development of efficient delivery systems. Although pDNA and ODN are novel candidates for nonviral gene therapy, their clinical applications are generally limited owing to their rapid degradation by nucleases in serum and rapid clearance. A great deal of effort
✦ LIBER ✦
Targeting delivery of oligonucleotide and plasmid DNA to hepatocyte via galactosylated chitosan vector
✍ Scribed by Shuying Gao; Jiangning Chen; Lei Dong; Zhi Ding; Yong-hua Yang; Junfeng Zhang
- Book ID
- 116437401
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- French
- Weight
- 265 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0939-6411
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## Abstract ## Background The ability to deliver plasmid DNA (pDNA) to specific cells __in vivo__ is crucial for achieving efficient targeted transfection with nonviral vectors. We previously used stealth liposomes containing the chelator lipid 3(nitrilotriacetic acid)‐ditetradecylamine (NTA~3~‐DT