Targeting death receptor induced apoptosis and necroptosis: A novel therapeutic strategy to prevent neuronal damage in retinal detachment

Necroptosis, a novel form of caspase-ind

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

✍ Daniel M. Rosenbaum; Alexei Degterev; Joel David; Pearl S. Rosenbaum; Steven Rot 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 617 KB

## Abstract Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional impairment in a model of retinal ischemia. Methods: Sprague‐Dawley rats were subjected to raised intra‐ocular pressure for 45 min a