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Targeting Cell Surface Receptors with Ligand-Conjugated Nanocrystals

✍ Scribed by Rosenthal, Sandra J.; Tomlinson, Ian; Adkins, Erika M.; Schroeter, Sally; Adams, Scott; Swafford, Laura; McBride, James; Wang, Yongqiang; DeFelice, Louis J.; Blakely, Randy D.


Book ID
125498680
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
305 KB
Volume
124
Category
Article
ISSN
0002-7863

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High-affinity receptors expressed on the surface of some tumors can be exploited by chemically conjugating the ligand for the receptor and an antibody against immune effector cells, thus redirecting their cytolytic potential against the tumor. Ovarian carcinomas and some brain tumors express the hig