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Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism

✍ Scribed by Tsialogiannis, Evaggelos; Polyzois, Ioannis; Tang, Quen Oak; Pavlou, George; Tsiridis, Evgenios; Heliotis, Manolis; Tsiridis, Eleftherios

Book ID
125473014
Publisher
Informa plc
Year
2008
Tongue
English
Weight
308 KB
Volume
13
Category
Article
ISSN
1472-8222

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Recombinant human bone morphogenetic protein-2 (rhBMP-2) was biotinated, and the bioactivity of biotinated protein was assessed in vitro (alkaline phosphate induction in limb bud cells) and in vivo (osteoinduction in the rat ectopic assay). Amino-biotinated rhBMP-2 exhibited an increase in bioactivi